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Visar resultat 1 - 5 av 4265 avhandlingar som matchar ovanstående sökkriterier.
1. Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds
Sammanfattning : Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the ruggedness of the method acquiring the results. In addition to the complexity of the sample matrix, the bioactive compounds targeted for analysis usually have low levels of natural abundance, further increasing the demand on the analytical method sensitivity. LÄS MER
2. Quantitative SPECT : studies of some factors influencing quantitation accuracy in single photon emission computed tomography
Sammanfattning : .... LÄS MER
3. Quantitative Surface Enhanced Raman Spectroscopy
Sammanfattning : Surface enhanced Raman spectroscopy (SERS) is a very attractive technique for detection of various organic and inorganic molecules due to its sensitivity and selectivity. The surface enhancement is achieved when the molecules of interest are on or in the vicinity of a metal surface, usually gold and silver. LÄS MER
4. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications
Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER
5. Pharmacometric Models to Improve Treatment of Tuberculosis
Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER