Sökning: "protein structure prediction"

Visar resultat 21 - 25 av 93 avhandlingar innehållade orden protein structure prediction.

1. 21. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER

3. 22. From protein sequence to structural instability and disease

   Författare :Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
   Nyckelord :protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

   Sammanfattning : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. LÄS MER

4. 23. New methods for protein structure threading and domain identification

   Författare :Mats Lindstam; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomatematik; Molecular biophysics; Molekylär biofysik; medicinsk informatik; Bioinformatik; biomathematics biometrics; medical informatics; structure prediction; Bioinformatics; domain identification; Structural bioinformatics; threading;

   Sammanfattning : The availability of three-dimensional structures of proteins has provided enormous insight into the detailed molecular machinery of the living cell. Since the late 1950s and early 1960s, experimental methods for deriving protein structures have contributed more than 30,000 entries to the Protein Data Bank, representing the collected knowledge of protein and other macromolecular structures. LÄS MER

5. 24. Decipher protein complex structures from sequence

   Författare :Wensi Zhu; Arne Elofsson; Nathalie Reuter; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein complex structure prediction; protein interaction; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : Proteins are essential constituents of biological systems. A profound understanding of protein structure is significant for unraveling the intricate mechanisms of biological processes. The recent development of computational methods using AI technology is revolutionizing the structural biology field. LÄS MER

7. 25. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Författare :Magnus Palmblad; Ole Nørregaard Jensen; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; Peptide; protein; peptide mass fingerprinting; identification; sequencing; protein structure; non-covalent interaction; modification; electrospray ionization; liquid chromatography; capillary electrophoresis; electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyloid β-peptide; Alzheimer’s disease.; Materialvetenskap; Materials science; Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. LÄS MER