Sökning: "protein structure prediction"

Visar resultat 16 - 20 av 93 avhandlingar innehållade orden protein structure prediction.

1. 16. Mutational effects on protein structure and function

   Författare :Jonas Carlsson; Persson Bengt; Uwe Sauer; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mutation; prediction; phenotypes; homology model; virtual screening; molecular dynamics; amyloid; cancer; membrane protein; Bioinformatics; Bioinformatik;

   Sammanfattning : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. LÄS MER

3. 17. Genome-wide structural and functional protein characterization by ab initio protein structure prediction

   Författare :Lars Malmström; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biomedicinska vetenskaper; Biomedical sciences; Saccharymyces cerevisiae; Ab initio protein structure prediction; Protein annotation;

   Sammanfattning : Very little is known about a considerable part of all proteins and it is time consuming and expensive to study each individual protein to determine its function, structure and cellular role. Proteins retain structural, functional and sequential characteristics from ancestral proteins and hence two proteins that share a common ancestor, i.e. LÄS MER

4. 18. Protein Model Quality Assessment : A Machine Learning Approach

   Författare :Karolis Uziela; Arne Elofsson; Liam McGuffin; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Model Quality Assessment; structural bioinformatics; machine learning; deep learning; support vector machine; proq; Artificial Neural Network; protein structure prediction; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Many protein structure prediction programs exist and they can efficiently generate a number of protein models of a varying quality. One of the problems is that it is difficult to know which model is the best one for a given target sequence. Selecting the best model is one of the major tasks of Model Quality Assessment Programs (MQAPs). LÄS MER

5. 19. Engineering of Antibacterial Phage-Derived Proteins

   Författare :Fredrik Seijsing; Anders Nilsson; Yves Briers; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; endolysin; IgG; linker protein; chimeric protein; artificial opsonin; spider silk; antibacterial surface; bacteriophage; structure prediction; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The increasing threat of antibiotic resistance calls for the development of new treatment methods. Bacteriophages are interesting candidates since they can lyse bacteria with great efficiency. Bacteriophages produce enzymes called endolysins which break down the peptidoglycan in the cell wall at the end of the infection cycle. LÄS MER

7. 20. Formalizing life : Towards an improved understanding of the sequence-structure relationship in alpha-helical transmembrane proteins

   Författare :Håkan Viklund; Arne Elofsson; Kimmen Sjölander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; protein; topology; hidden Markov model; prediction; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Sammanfattning : Genes coding for alpha-helical transmembrane proteins constitute roughly 25% of the total number of genes in a typical organism. As these proteins are vital parts of many biological processes, an improved understanding of them is important for achieving a better understanding of the mechanisms that constitute life. LÄS MER