Sökning: "preclinical studies"

Visar resultat 11 - 15 av 196 avhandlingar innehållade orden preclinical studies.

  1. 11. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

    Författare :Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

    Sammanfattning : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. LÄS MER

  3. 12. Boron neutron capture therapy : preclinical studies of compounds for tumour targeting

    Författare :Lars Gedda; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 13. Aspects of Tumour Targeting : Preclinical Studies on Human Malignant Cells in vitro

    Författare :Maria Dahlström Wester; Annelie Lindström; Åke Wasteson; Lars Gedda; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Exclusive eradication of tumour cells causing minimal damage to healthy tissue, a concept referred to as targeting, is an interesting approach to improve the outcome for patients afflicted with cancer.The general aim of this thesis was to highlighten aspects that could be of importance in developing novel treatment regimens based on specific targeting of tumour cells. LÄS MER

  5. 14. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Författare :Camilla Björn; RISE; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance; Antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Sammanfattning : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. LÄS MER

  7. 15. Preclinical Characterization in vivo and in vitro of Novel Agents for Cancer Chemotherapy : Studies on Benomyl, Carbendazim, Cryptolepine and Acriflavine

    Författare :Daniel Laryea; Peter Nygren; Moustapha Hassan; Uppsala universitet; []
    Nyckelord :Benzimidazoles; cryptolepine; acriflavine; cancer; high throughput screening; cytotoxic drug; gene expression;

    Sammanfattning : Preclinical methods for the identification and characterization of molecules for development into new cancer drugs were investigated. Based on repurposing, i.e. LÄS MER