Sökning: "preclinical studies"
Visar resultat 21 - 25 av 195 avhandlingar innehållade orden preclinical studies.
21. Preclinical studies of ribozyme-mediated gene therapy for HIV-1
Sammanfattning : Approximately 40 million people are infected with HIV-1 and AIDS is the number one cause of death in Africa as well as, the fourth leading cause of death globally. Patients in developed countries generally receive highly active antiretroviral therapy (HAART), even though the drugs are expensive and sometimes cause side-effects and treatment failure. LÄS MER
22. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis
Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER
23. Urinary bladder carcinoma, preclinical and clinical studies on EGFR based targeting
Sammanfattning : Radical cystectomy with bilateral pelvic lymphadenectomy is the standard treatment for muscle-invasive transitional cell carcinoma of the urinary bladder. Despite presumably localised malignancies and efficacious management about 50% of patients will die within 5 years, the majority due to metastatic disease. LÄS MER
24. Analytical and pharmacological studies of cyclophosphamide
Sammanfattning : Pharmacokinetic and pharmacodynamic studies are an essential in order to achieve better treatment efficacy and less drug related toxicity. The kinetic studies depend on measuring the drug concentrations in body fluids. LÄS MER
25. Biomarkers in preclinical familial Alzheimer disease
Sammanfattning : Background: Alzheimer disease (AD) is a neurodegenerative disorder, characterized by the accumulation of b-amyloid (Ab) plaques and tangles consisting of hyperphosphorylated tauprotein in the brain. It accounts for 60-70% of dementia cases, making it the most common cause of dementia. LÄS MER