Sökning: "preclinical studies"

Visar resultat 6 - 10 av 196 avhandlingar innehållade orden preclinical studies.

  1. 6. Preclinical studies of roscovitine

    Författare :Marina Vita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

    Sammanfattning : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. LÄS MER

  3. 7. Anticancer Activity of Melflufen : Preclinical Studies of a Novel Peptidase-Potentiated Alkylator

    Författare :Sara Strese; Joachim Gullbo; Rolf Larsson; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancertherapy; preclinical studies; melflufen; aminopeptidase-potentiated; cancer; angiogenesis; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Melflufen (melphalan flufenamide, chemical name L-melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride, previously called J1) is a derivative of the classical alkylating agent melphalan. Melflufen is potentiated by hydrolytic cleavage by aminopeptidase N (APN), leading to high intracellular concentrations of alkylating moieties and subsequent cell death. LÄS MER

  4. 8. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

    Författare :Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. LÄS MER

  5. 9. Preclinical Studies for Cryoprevention of Oral Mucositis

    Författare :Java Walladbegi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Animal model; Chemotherapy; Cryotherapy; Hematopoietic stem cell transplantation; Ice chips; Intraoral cooling device; Microcirculation; Randomized controlled trial; Tissue-engineered oral mucosa; Tissue oxygen saturation; Tolerability;

    Sammanfattning : Oral mucositis (OM) is a debilitating adverse effect, with a prevalence of up to 80% in patients with cancer who are conditioned with high-dose chemotherapy prior to hematopoietic stem cell transplantation. In its mildest form, OM is characterized by erythema. However, as it worsens, it can give rise to painful ulcerations in the oral mucosa. LÄS MER

  7. 10. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer

    Författare :Marika Nestor; Matti Anniko; Jörgen Carlsson; Hans Lundqvist; Vladimir Tolmachev; Matthew Robinson; Uppsala universitet; []
    Nyckelord :Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Sammanfattning : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. LÄS MER