Sökning: "antimicrobial resistance"

Visar resultat 1 - 5 av 154 avhandlingar innehållade orden antimicrobial resistance.

  1. 1. Bacterial Resistance to Antimicrobial Peptides : Rates, Mechanisms and Fitness Effects

    Författare :Maria Pränting; Dan Andersson; Ian Chopra; Uppsala universitet; []
    Nyckelord :antimicrobial peptides; antibiotic resistance; fitness cost; bacterial evolution; small colony variants; cyclotides; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Mikrobiologi; Microbiology;

    Sammanfattning : The rapid emergence of bacterial resistance to antibiotics has necessitated the development of alternative treatment strategies. Antimicrobial peptides (AMPs) are important immune system components that kill microbes rapidly and have broad activity-spectra, making them promising leads for new pharmaceuticals. LÄS MER

  2. 2. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Författare :Camilla Björn; RISE; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance; Antimicrobial peptides;

    Sammanfattning : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. LÄS MER

  3. 3. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides

    Författare :Lukas Boge; Martin Andersson; Lovisa Ringstad; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; infection; phase behavior; antimicrobial effect; Liquid crystals; hexosome; antimicrobial resistance; AMP; antimicrobial peptide; pulmonary delivery; topical delivery; glycerol monooleate; bacterial membrane; cubosome; liquid crystalline nanoparticles; membrane interaction; proteolysis;

    Sammanfattning : The development of antimicrobial resistance is a great challenge within health sectors worldwide. Thus, demand for new, efficient treatments is urgent in order to treat various bacterial infections. Antimicrobial peptides (AMPs) are a group of antibiotics that have gained more and more attraction in the past decade. LÄS MER

  4. 4. Aspects of Bacterial Resistance to Silver

    Författare :Susanne Sütterlin; Åsa Melhus; Björn Olsen; Roland Möllby; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial resistance; Silver resistance; Clinical Bacteriology; Klinisk bakteriologi;

    Sammanfattning : Bacterial resistance to antibiotics has increased rapidly within recent years, and it has become a serious threat to public health. Infections caused by multi-drug resistant bacteria entail higher morbidity, mortality, and a burden to health care systems. LÄS MER

  5. 5. Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides

    Författare :Hava Lofton Tomenius; Dan I Andersson; Ørjan Samuelsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; antibiotic resistance; fitness cost; Salmonella Typhimurium; Staphylococcus aureus; bile; serum; pH response; growth rate; mice; phoP; pmrB; waaY; LPS; LL-37; defensins; membrane potential; Mikrobiologi; Microbiology;

    Sammanfattning : The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. LÄS MER