Sökning: "platelet activating factor"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden platelet activating factor.

  1. 16. Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D

    Författare :Annica Pontén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelet-derived growth factors (PDGFs) belong to the PDGF/VEGF (vascular endothelial growth factor) family of growth factors. Members of this family share a common structural feature, a conserved PDGF/VEGF homology domain, containing eight invariant cysteine residues. LÄS MER

  3. 17. Intestinal Ischemia and Reperfusion Injury - Pathophysiology as basis for novel treatment

    Författare :Zhengwu Sun; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ dysfunction; epithelium; endothelium; adhesion molecules; cytokines; protease inhibitor; Intestine; barrier; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Intestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction, as well as potential preventive and therapeutic modes of management were evaluated in the rat. LÄS MER

  4. 18. Intestinal ischemia and reperfusion. Proinflammatory response and organ dysfunction

    Författare :Knut Olanders; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; inflammation; cytokine; leukocyte; reperfusion; ischemia; permeability; Intestine; endothelium;

    Sammanfattning : Intestinal I/R is considered to be an important initiating event in several pathophysiological conditions such as trauma, bleeding, sepsis and pancreatitis, frequently leading to concomitant both single and potentially multiple organ dysfunction. The purpose of this thesis was to study mechanims underlying the development of multiple organ dysfunction, with special focus on intercellular proinflammatory regulation in the concurrent development of tissue injury. LÄS MER

  5. 19. Imaging methods for haemostasis research

    Författare :Lars Faxälv; Tomas Lindahl; Pentti Tengvall; Rolf Larsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Blood is a vital part of the human physiology; a transport system that brings nutrients and oxygen to sustain living cells and simultaneously facilitates the removal of carbon dioxide and other waste products from the body. To assure the continuity of these functions, it is of uttermost importance to keep the flowing blood inside the vascular system at any cost. LÄS MER

  7. 20. Regulation and Function of MAP Kinases in PDGF Signaling

    Författare :Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. LÄS MER