Sökning: "neglected tropical disease"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden neglected tropical disease.

  1. 1. Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

    Författare :Giulia Opassi; Helena Danielson; Jenny Sandmark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neglected Tropical Diseases; Drug Discovery; Biochemistry; Biophysics; Kinetic; Fragment Based Lead Discovery; Assay Development;

    Sammanfattning : Even though they account for 10% of the global disease burden and besides the new record of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical companies and public funding. The reason can be mostly found in the fact that for these diseases a conventional drug discovery process is often too expensive. LÄS MER

  2. 2. It is on my skin, on my soul, and on my life : development of a disease-specific quality of life instrument for adult patients with acute cutaneous leishmaniasis in Iran

    Författare :Alireza Khatami; Berndt Stenberg; Maria Emmelin; Hans Stenlund; Farhad Handjani; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cutaneous leishmaniasis; fundamental measurement; needs-based approach; neglected tropical disease; probabilistic model; quality of life; qualitative content analysis; the Rasch model; epidemiologi; Epidemiology;

    Sammanfattning : Background: Cutaneous leishmaniasis (CL), is the most common form of a group of diseases known as leishmaniases. They are caused by obligatory intracellular protozoa from the genus Leishmania and transmitted by sandflies. LÄS MER

  3. 3. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Författare :Mikael Boberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Sammanfattning : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. LÄS MER

  4. 4. Control or elimination : terms for public health interventions against tungiasis and schistosomiasis haematobium

    Författare :Per Nordin; Ingela Krantz; Stig Wall; Andreas Ruppel; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tungiasis; urogenital schistosomiasis; control; elimination; public health; intervention; diagnosis; treatment; neglected tropical diseases; praziquantel; mass treatment; Public health; folkhälsa;

    Sammanfattning : The thesis revolves around diagnosis and treatment of tungiasis (sand flea disease) and schistosomiasis haematobium. The causing parasites, Tunga penetrans and Schistosoma haematobium, both have the ability to penetrate intact skin. LÄS MER

  5. 5. Chemosensation in Aedes aegypti: from molecular response profiles to host-seeking behaviour

    Författare :Anaïs Tallon; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The female mosquito Aedes aegypti is the primary urban vector of various highly infectious neglected tropical diseases. Disease transmission relies heavily on odourmediated behaviours, including e.g., sugar- and host-seeking, which are crucial during the mosquito life cycle and has dire impacts on vectorial capacity. LÄS MER