Sökning: "naturvetenskap kemi organisk kemi organisk syntes"

Visar resultat 16 - 20 av 128 avhandlingar innehållade orden naturvetenskap kemi organisk kemi organisk syntes.

1. 16. Optimering i organisk syntes : betingelser, system, syntesvägar

   Författare :Lars Hansson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; Response surface method; PLS method; Silylation; Enolether; Unsaturated ketones; Diketones; Geosmin synthesis; Onepot procedure;

   Sammanfattning : This thesis deals with different optimization problems encountered in organic synthesis. The use of response surface, sequential simplex and PLS techniques, for simultanious optimization of yield and suppression of side reactions is investigated. This is illustrated by an example of enamine synthesis, were a side reaction was a serious problem. LÄS MER

3. 17. Pharmacophore Refinement and Lead Optimization - A study of the benzodiazepine site of the GABAA receptors

   Författare :Erik Lager; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Naturvetenskap; Natural science; Quinolone; Flavone; Pharmacophore; GABA; Benzodiazepine;

   Sammanfattning : Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). LÄS MER

4. 18. Coordination chemistry of late transition metals with PCP ligands. Synthesis, catalysis and mechanism

   Författare :Daniel Olsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organometallic chemistry; Metallorganisk kemi; Organic chemistry; Oorganisk kemi; Inorganic chemistry; Suzuki reaction; Stille reaction; catalysis; cyclometalation; C-H activation; PCP complex; POCOP ligand; PCP ligand; iridium; palladium; platinum;

   Sammanfattning : Abstract The work presented in this thesis discusses synthesis of PCP-complexes and utilisations of such organometallic compounds in catalysis. The complexes, obtained by intramolecular Csp3-H activation, are based on the metals palladium, platinum and iridium. LÄS MER

5. 19. Enantioselective Binding of Designed Propranolol Analogues to the Cellobiohydrolase Cel7A

   Författare :Alexandra Fagerström; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Structure chemistry; enzymologi; Proteiner; enzymology; Proteins; Naturvetenskap; Natural science; capillary electrophoresis; chiral recognition; enantiomeric selectivity; cellobiohydrolase Cel7A; propranolol; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes the affinity and enantiomeric selectivity of the cellobiohydrolase Cel7A (isolated from Hypocrea jercorina). The chiral recognition of the enzyme has been studied with respect to amino alcohols and new ligands have been designed, based on the structure of the common ?-blocker propranolol. LÄS MER

7. 20. TRÖGER´S BASE AS SCAFFOLD FOR SYNTHETIC RECEPTORS

   Författare :Carlos Solano; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Organisk kemi; Organic chemistry; Makromolekylär kemi; Macromolecular chemistry; Molecular Recognition; Tröger´s base; Synthetic Receptors; Fysikalisk kemi;

   Sammanfattning : This work focuses on the use of the Tröger´s base as organic scaffold for the construction of synthetic receptors for different classes of organic molecules. The structural properties of the Tröger's base, i.e. chirality, rigidity and curvature, allow for synthetic modifications towards the recognition of different molecules. LÄS MER