Sökning: "Quinolone"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet Quinolone.

  1. 1. Pharmacophore Refinement and Lead Optimization - A study of the benzodiazepine site of the GABAA receptors

    Författare :Erik Lager; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Naturvetenskap; Natural science; Quinolone; Flavone; Pharmacophore; GABA; Benzodiazepine;

    Sammanfattning : Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). LÄS MER

  3. 2. Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens

    Författare :Herin Oh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Quinolone; resistance; B. fragilis; P. aeruginosa; topoisomerase; efflux;

    Sammanfattning : Opportunistic pathogens can cause infections in case of structural or functional defects in the host. Examples of Gram-negative opportunists are the Bacteroides fragilis group, anaerobic, non-spore forming rods and the aerobic, non-fermentative rod Pseudomonas aeruginosa. LÄS MER

  4. 3. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa

    Författare :Shah Jalal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :quinolone resistance; P. aeruginosa; PCR; DNA sequencing; mutation; NIRCA; RESA; multidrug efflux; cystic fibrosis;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. LÄS MER

  5. 4. Design and synthesis of steroid mimetic libraries using solid phase techniques

    Författare :Marcus Ruda; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pyridone; quinolone; benzoindazole; solid phase chemistry; scavenger resin; combinatorial chemistry; alpha-arylation; nuclear hormone receptor; steroid mimetic.;

    Sammanfattning : This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure was designed mimicking the ABC-rings of a steroid. LÄS MER

  7. 5. On the development of low level resistance in gram-positive and gram-negative bacteria after antibiotic exposure

    Författare :Gunilla Rådberg; Signe Ringertz; Östergötlands Läns Landsting; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Resistance has been found to develop and spread via several mechanisms against virtually all clinically available antimicrobial agents. Increasing use of antibiotics has been shown to correlate to increasing incidence of bacterial resistance. LÄS MER