Sökning: "Benzodiazepine"
Visar resultat 1 - 5 av 39 avhandlingar innehållade ordet Benzodiazepine.
1. Pharmacophore Refinement and Lead Optimization - A study of the benzodiazepine site of the GABAA receptors
Sammanfattning : Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). LÄS MER
2. Benzodiazepine and opioid dependence. Clinical and meta-analytical studies
Sammanfattning : The thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. LÄS MER
3. Taste Hedonics and the Intake of Alcohol and Food
Sammanfattning : This thesis includes four papers based on animal experimental work. They analyze the way in which activation of a specific motivational state - hunger- modulates the rewarding actions of alcohol and taste palatability. LÄS MER
4. Alcohol problems in women; Gender characteristics relevant for identification in clinical and health screening settings
Sammanfattning : This thesis presents data relating to gender differences of problem drinking. The aim was to increase the knowledge of characteristics of female problem drinking to enhance identification efficiency. LÄS MER
5. Design and Synthesis of AT2 Receptor Selective Angiotensin II Analogues Encompassing β- and γ-Turn Mimetics
Sammanfattning : Important information on the bioactive conformation of biologically active peptides may be obtained by studies of rigid peptides or well-defined secondary structure mimetics incorporated into pseudopeptides. The structural requirements for the interaction of angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) with its AT1 and AT2 receptors were the subject of this study. LÄS MER