Sökning: "C-H activation"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden C-H activation.

  1. 1. Regulation of Intracellular Calcium in Brown Adipocytes

    Författare :Shi-Jin Zhang; Lawrence C.H Wang; Stockholms universitet; []

    Sammanfattning : Intracellular Ca2+ is considered a primary regulator of cell function. In the present study, the control and the effects of intracellular Ca2+ in brown adipocytes have been investigated. Cytosolic Ca2+ levels ([Ca2+]i) are the resultant of the activity of Ca2+ transport systems. LÄS MER

  2. 2. Ruthenium-catalyzed C-H Functionalization of (Hetero)arenes

    Författare :Karthik Devaraj; Lukasz T. Pilarski; Victor A. Snieckus; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; catalysis; C-H activation; heterocycles; ruthenium; aryne precursor; silylation; gramine;

    Sammanfattning : This thesis concerned about the Ru-catalyzed C-H functionalizations on the synthesis of 2-arylindole unit, silylation of heteroarenes and preparation of aryne precursor.In the first project, we developed the Ru-catalyzed C2-H arylation of N-(2-pyrimidyl) indoles and pyrroles with nucleophilic arylboronic acids under oxidative conditions. LÄS MER

  3. 3. Palladium Catalysis in Directed C-H Bond Activation and Cycloisomerisation Reactions

    Författare :Michael Oschmann; Jan-Erling Bäckvall; Oscar Verho; Jose Luis Mascareñas; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Palladium II ; Catalysis; C-H Functionalisation; Transamidation; XAS; organisk kemi; Organic Chemistry;

    Sammanfattning : The main focus of this thesis concerns the development of Pd(II)-catalysed synthetic methodologies for the preparation of biologically active compounds.In the first part (paper I-III), unactivated C–H bonds of a cyclobutane derivative are selectively functionalised using a directing group starting from the feedstock compound verbenone (paper I). LÄS MER

  4. 4. Iridium-Catalyzed C−H Activation Methods for Late-Stage Functionalization of Pharmaceuticals

    Författare :Erik Weis; Belén Martín‐Matute; Jin-Quan Yu; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; amination; catalysis; C-H activation; C-H functionalization; high-throughput experimentation; iodination; iridium; isotope labelling; late-stage functionalization; methylation; Organic Chemistry; organisk kemi;

    Sammanfattning : C-H activations have over the recent decades risen from a mere curiosity to a viable synthetic strategy. However, challenges in terms of accessible transformations, selectivity and functional group tolerance limit the widespread applicability of this approach. LÄS MER

  5. 5. C-H Activation Reactions Mediated by Pd Based Heterogeneous Catalysts : Regioselective Formation of C-O and C-X Bonds

    Författare :Maitham Majeed; Centrum för analys och syntes; []
    Nyckelord :C-H Activation; N-heterocyclic carbenes; palladium; polymer supported Pd II ; undirected acetoxylation; directed halogenation; continuous flow; reduced graphene oxide supported Pd II ;

    Sammanfattning : New classes of N-heterocyclic carbene-palladium(II) complexes containing either a vinyl group in different positions or an anthracene tag in the backbone of the N-heterocycle were synthesized and fully characterized. The vinyl based complexes were copolymerized with divinylbenzene to fabricate robust polymer-supported NHC-Pd(II) systems, while the anthracene based complexes were π-stacked onto the surface of reduced graphene oxide (rGO) producing immobilized catalysts with interesting features. LÄS MER