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Visar resultat 1 - 5 av 13 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Myocardial ischemia and reperfusion injury, clinical and experimental studies

    Författare :Karin Åström-Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardium; ischemia; reperfusion injury; FKBP12; FKBP12.6;

    Sammanfattning : Acute myocardial infarction is the consequence of an occluded nutrient coronary artery. Reperfusion reduces infarct size and enhances the rate of survival. But reperfusion may also, in itself, cause reversible injury, stunning and arrhythmias, as well as irreversible lethal reperfusion injury. LÄS MER

  3. 2. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER

  4. 3. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    Författare :Fei Tian; Göteborgs universitet; []
    Nyckelord :hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Sammanfattning : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. LÄS MER

  5. 4. Adult Stem Cell Plasticity, Hype or Hope?

    Författare :Jalal Taneera; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; pancreatic beta cell ; stem cell ; plasticity ; Medicin människa och djur ;

    Sammanfattning : Several studies have reported that bone marrow (BM)-derived stem cells have the capacity to give rise to cells of different type of tissue; an ability termed stem cell plasticity or transdifferentiation. Controversies exist as to how frequent this phenomenon is, or if it may be explained by alternative mechanisms. LÄS MER

  7. 5. Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation

    Författare :Agneta Månsson Broberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myocardial infarction; ischemia; angiogenesis; VEGF- A165; gene therapy; adenovirus; plasmid; ephrinB2; darbepoietin-alpha; apoptosis; estrogen receptors;

    Sammanfattning : Background: Therapeutic angiogenesis using i.e. VEGF and FGF have shown beneficial effects, however, delivery routes and other modulating agents have not been thoroughly investigated. In this study the efficacy of adenovirus gene transfer was compared to plasmid gene transfer. LÄS MER