Sökning: "molekyler"

Visar resultat 6 - 10 av 579 avhandlingar innehållade ordet molekyler.

  1. 6. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy

    Författare :Charles Dahlsson Leitao; Stefan Ståhl; John Löfblom; Christoph Rader; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; radionuclide imaging; affibody molecules; HER-receptors; prodrug; protein design; Cancerterapi; radionuklidavbildning; affibody molekyler; HER-receptorer; prodrog; proteindesign; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. LÄS MER

  3. 7. Platforms and strategies harnessing signaling pathways of multifactorial diseases by multispecific antibodies

    Författare :Aman Mebrahtu; Johan Rockberg; Fredrik Y. Frejd; Janine Schuurman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibodies; Bispecific antibodies; Multispecific affinity proteins; Protein engineering; Protein expression; Cancer; Immunotherapy; Autoimmunity; Systemic Lupus Erythematosus; Affibody molecules; AffiMab; Antikroppar; Bispecifika antikroppar; Multispecifika affinitets protein; Protein engineering; Protein uttryck; Cancer; Immunoterapai; Autoimmunitet; Systemic Lupus Erythematosus; Affibody molekyler; AffiMab; Biotechnology; Bioteknologi;

    Sammanfattning : Abstract [ENG]Proteins govern a multitude of biological functions vital to sustain life. The ability to withstand diseases development and harboring a defense against foreign pathogens is attributed to the wonders of the immune system and the proteins and cells its comprised of. LÄS MER

  4. 8. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

    Författare :Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
    Nyckelord :Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

    Sammanfattning : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. LÄS MER

  5. 9. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Författare :Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Sammanfattning : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. LÄS MER

  7. 10. Molecular design, synthesis and performance evaluation of phenothiazine-based small molecules for efficient organic solar cells

    Författare :Srikanth Revoju; Bertil Eliasson; Haining Tian; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic solar cell; small molecule donors; phenothiazine; power conversion efficiency; organisk kemi; Organic Chemistry;

    Sammanfattning : Photovoltaics offers one of the most promising routes to generate electricity in a clean way. As an emerging technology in photovoltaics, organic solar cells (OSC) have attracted a great deal of attention owing to their potential low-cost, lightweight, flexibility and solution processability. LÄS MER