Sökning: "CD38"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet CD38.

  1. 1. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

    Författare :Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
    Nyckelord :Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

    Sammanfattning : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. LÄS MER

  3. 2. Telomere length as prognostic parameter in chronic lymphocytic leukemia

    Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER

  4. 3. Hematopoietic stem cells: c-mpl and TNF receptor function

    Författare :Veslemøy Ramsfjell; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor necrosis factor-a.; in vivo reconstitution; ex vivo expansion; long-term bone marrow culture; differentiation; proliferation; synergy; Hematopoietic stem cells; thrombopoietin; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Hematopoietic stem cells (HSC) are crucial to life. Daily and throughout the life span of an individual they are responsible for replacing approximately 10(12) mature blood cells. Mature cells are, for example, required for transportation of oxygen, defense against infections and to stop bleeding. LÄS MER

  5. 4. Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells

    Författare :Maria Karvouni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival rates, patients still experience relapse and cure remains elusive. LÄS MER

  7. 5. Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia

    Författare :Nils Hansen; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; SOCS2; IL1RAP; BCR ABL1; leukemia models;

    Sammanfattning : Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. LÄS MER