Sökning: "prodrug"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet prodrug.

  1. 1. Tertiary haloalkylamines related to pharmacologically active agents : a prodrug principle

    Författare :Björn Lindborg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  3. 2. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

    Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

  4. 3. Preclinical Studies of the Melphalan Prodrug J1 for Cancer Therapy

    Författare :Malin Wickström; Joachim Gullbo; Rolf Larsson; Johan Hansson; Uppsala universitet; []
    Nyckelord :Pharmacology; Pharmacology; Chemotherapy; Melphalan prodrug; Cancer; Farmakologi;

    Sammanfattning : J1 (L-melphalanyl-L-p-fluorophenylalanyl ethyl ester) is a dipeptide derivative of the alkylating agent melphalan with increased cytotoxicity. In this thesis the preclinical pharmacology of J1 has been characterized.Our results show that J1 rapidly enters the cells, where melphalan is released by hydrolysis. LÄS MER

  5. 4. Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis

    Författare :Sanela Kurtovic; Bengt Mannervik; Ulf Hellman; Denis Pompon; Uppsala universitet; []
    Nyckelord :Biochemistry; DNA shuffling; substrate selectivity; mutant library; glutathione transferase; multivariate data analysis; prodrug; Biokemi;

    Sammanfattning : Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. LÄS MER

  7. 5. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy

    Författare :Charles Dahlsson Leitao; Stefan Ståhl; John Löfblom; Christoph Rader; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; radionuclide imaging; affibody molecules; HER-receptors; prodrug; protein design; Cancerterapi; radionuklidavbildning; affibody molekyler; HER-receptorer; prodrog; proteindesign; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. LÄS MER