Sökning: "Joel L. Sussman"

Hittade 2 avhandlingar innehållade orden Joel L. Sussman.

1. 1. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

   Författare :Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

   Sammanfattning : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. LÄS MER

3. 2. Life will find a way : Structural and evolutionary insights into FusB and HisA

   Författare :Xiaohu Guo; Maria Selmer; Joel L. Sussman; Uppsala universitet; []
   Nyckelord :HisA; TrpF; protein evolution; bi-functional enzyme; fusidic acid; antibiotic resistance; protein synthesis; FusB;

   Sammanfattning : How do microbes adapt to challenges from the environment? In this thesis, two distinct cases were examined through structural and biochemical methods. In the first, we followed a real-time protein evolution of HisA to a novel function. The second case was fusidic acid (FA) resistance mediated by the protein FusB in Staphylococcus aureus. LÄS MER