Sökning: "molecule concept"
Visar resultat 6 - 10 av 76 avhandlingar innehållade orden molecule concept.
6. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1
Sammanfattning : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. LÄS MER
7. Polypeptide Conjugates as High-affinity Binders for Proteins
Sammanfattning : A novel concept for protein recognition has been developed. The recognition unit is a hybrid molecule obtained by conjugation of a small organic molecule to a synthetic polypeptide selected from a 16-membered set of 42 amino acid residue sequences. The sequences are unordered and have no prior relation to the target proteins. LÄS MER
8. Polymer brush functionalised nanopore sensors
Sammanfattning : Single-molecule studies on proteins could reveal a lot of information about their conformational dynamics, and processes such as misfolding and aggregation. This knowledge is valuable in providing a deeper understanding of molecular biology, and for understanding the link between proteins and various diseases. LÄS MER
9. Development of catalytic enantioselective C-C bond-forming and cascade transformations by merging homogeneous or heterogeneous transition metal catalysis with asymmetric aminocatalysis
Sammanfattning : Chiral molecules play a central role in our daily life and in nature, for instance the different enantiomers or diastereomers of a chiral molecule may show completely different biological activity. For this reason, it is a vital goal for synthetic chemists to design selective and efficient methodologies that allow the synthesis of the desired enantiomer. LÄS MER
10. Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions
Sammanfattning : Dynamic systems for screening, control and identification of different protein-ligand interactions are presented. Dynamic chemistry is used to produce new compounds/constituents in situ that can interact with a target molecule. Several entities can be introduced at the same time and interact with one another. LÄS MER