Sökning: "polypeptide conjugates"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden polypeptide conjugates.

1. 1. Peptide Conjugates as Useful Molecular Tools

   Författare :Adam T. Ślósarczyk; Lars Baltzer; Knud J. Jensen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide conjugates; designed peptides; polypeptides; molecular recognition; linker; linking technology; bioconjugation; conjugation; conjugates; Kemi; Chemistry; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

   Sammanfattning : The conjugation of a small organic molecule to synthetic polypeptides from a designed set has been shown to give rise to binders with high affinity and selectivity for the phosphorylated model proteins α-casein and β-casein but not for ovoalbumin. The small organic molecule that was used for this purpose is comprised of two di-(2-picolyl)amine groups assembled on a dimethylphenyl scaffold, and is capable of complexing two Zn2+ ions to form chelates that bind the phosphate ion. LÄS MER

3. 2. Polypeptide Conjugates as High-affinity Binders for Proteins

   Författare :Lotta Tollstoy Tegler; Lars Baltzer; Amelie Eriksson Karlström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein recognition; polypeptide conjugates; peptide; molecular interactions; C-reactive protein; Acetylcholine esterase; Human Carboinc anhydrase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : A novel concept for protein recognition has been developed. The recognition unit is a hybrid molecule obtained by conjugation of a small organic molecule to a synthetic polypeptide selected from a 16-membered set of 42 amino acid residue sequences. The sequences are unordered and have no prior relation to the target proteins. LÄS MER

4. 3. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

   Författare :Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

   Sammanfattning : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. LÄS MER

5. 4. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications

   Författare :Aleksandra Balliu; Lars Baltzer; Oliver Seitz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; protein targets; molecular recognition; affinity enhancement; conjugation;

   Sammanfattning : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. LÄS MER

7. 5. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1

   Författare :Jie Yang; Jan Kihlberg; Morten Grötli; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; molecular recognition; peptide cyclization; protein targets;

   Sammanfattning : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. LÄS MER