Sökning: "Dynamic self-inhibition"

Hittade 2 avhandlingar innehållade orden Dynamic self-inhibition.

1. 1. Chemoenzymatic Resolution in Dynamic Systems : Screening, Classification and Asymmetric Synthesis

   Författare :Yan Zhang; Olof Ramström; Sabine Flitsch; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic systemic resolution; dynamic kinetic resolution; enzyme catalysis; transesterification; enzyme promiscuity; asymmetric synthesis; pattern recognition; self-inhibition.;

   Sammanfattning : This  thesis  is  divided  into  four  parts,  all  centered  around  Constitutional Dynamic  Chemistry  (CDC)  and  Dynamic  Kinetic  Resolution  (DKR)  using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification.   In  part  one,  an  introduction  to  CDC  and  DKR  is  presented,  illustrating  the basic  concepts,  practical  considerations  and  potential  applications  of  such dynamic systems, thus providing the background information for the studies in the following chapters. LÄS MER

3. 2. Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions

   Författare :Rikard Larsson; Olof Ramström; Michel R. Gagné; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; Dynamic kinetic combinatorial resolution; Catalytic screening; Transthiolesterification; Thiol disulfide interchange; Nitroaldol reaction; Lectins; Hydrolases; Dynamic self-inhibition; Organic chemistry; Organisk kemi;

   Sammanfattning : Dynamic systems for screening, control and identification of different protein-ligand interactions are presented. Dynamic chemistry is used to produce new compounds/constituents in situ that can interact with a target molecule. Several entities can be introduced at the same time and interact with one another. LÄS MER