Sökning: "molecular target"

Visar resultat 6 - 10 av 1121 avhandlingar innehållade orden molecular target.

  1. 6. Next generation molecular diagnostics using ultrasensitive sequencing

    Författare :Stefan Filges; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid biopsy; cell-free DNA; circulating tumor DNA; molecular diagnostics; next-generation sequencing; unique molecular identifiers; melanoma;

    Sammanfattning : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. LÄS MER

  3. 7. Towards the Rational Design of Molecularly Imprinted Polymers

    Författare :Håkan S Andersson; Ann-Christin Koch-Schmidt; Ian A Nicholls; Klaus Mosbach; Richard F Venn; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thermodynamics; Molecular Recognition; Polyvalency; Cooperativity; Electrostatic Interactions; Hydrophobic Effect; Chromatography; Frontal Analysis; HPLC; Spectroscopy; Molecularly Imprinted Polymer; Molecular Imprinting; Crown Ether; Template Polymerisation; Cyclodextrin; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik; molecular recognition; Biokemi;

    Sammanfattning : Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. LÄS MER

  4. 8. Modelling Approaches to Molecular Systems Biology

    Författare :David Fange; Måns Ehrenberg; Johan Elf; Terence Hwa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stochastic reaction-diffuion kinetics; antibiotic drugs; efflux pumps; amino acid biosynthesis; Min-system; rRNA operon; transcription; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Implementation and analysis of mathematical models can serve as a powerful tool in understanding how intracellular processes in bacteria affect the bacterial phenotype. In this thesis I have implemented and analysed models of a number of different parts of the bacterium E. coli in order to understand these types of connections. LÄS MER

  5. 9. Metal homeostasis as critical determinant for cellular fitness

    Författare :Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. LÄS MER

  7. 10. Functional aspects of wobble uridine modifications in yeast tRNA

    Författare :Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. LÄS MER