Sökning: "Elongator complex"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Elongator complex.

  1. 1. Physiological consequences of Elongator complex inactivation in Eukaryotes

    Författare :Tony Karlsborn; Anders Byström; Hans Ronne; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Elongator complex; wobble uridine modifications; IKBKAP; IKAP; Familial dysautonomia; Untargeted Metabolic profiling.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Mutations found in genes encoding human Elongator complex subunits have been linked to neurodevelopmental disorders such as familial dysautonomia (FD), rolandic epilepsy and amyotrophic lateral sclerosis. In addition, loss-of-function mutations in genes encoding Elongator complex subunits cause defects in neurodevelopment and reduced neuronal function in both mice and nematodes. LÄS MER

  3. 2. Functional aspects of wobble uridine modifications in yeast tRNA

    Författare :Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. LÄS MER

  4. 3. Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae

    Författare :Bo Huang; Anders Byström; Monica Rydén-Aulin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transfer RNA; Modified nucleoside; Elongator complex; Wobble uridine; Decoding; Molecular biology; Molekylärbiologi;

    Sammanfattning : Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). LÄS MER

  5. 4. Functional aspects of modified nucleosides in tRNA

    Författare :Hao Xu; Anders S. Byström; Damien Hermand; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tRNA modification; frameshifting; Elongator complex; Elp1p; Prb1p; proteolysis; glioma; TRM6 61; PKCα;

    Sammanfattning : Transfer ribonucleic acids (tRNAs) are extensively modified, especially their anticodon loops. Modifications at position 34 (wobble base) and 37 in these loops affect the tRNAs’ decoding ability, while modifications outside the anticodon loops, e.g. m1A58 of tRNAMeti, may be crucial for tRNA structure or stability. LÄS MER

  7. 5. Factors modulating tRNA biogenesis and function in Saccharomyces cerevisiae

    Författare :Fu Xu; Anders Byström; Marcus J. O. Johansson; Raffael Schaffrath; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Translation; tRNA biogenesis; suppressor tRNA; Elongator complex; wobble uridine modifications; SUP4; YPK9; SSD1; serine tRNA; synthetic lethality; yeast; biology; biologi; molekylärbiologi; Molecular Biology; Genetics; genetik;

    Sammanfattning : Transfer RNA (tRNA) genes are transcribed by RNA polymerase III as precursors that undergo multiple processing steps to form mature tRNAs. These steps include processing of the 5’ leader and 3’ trailer sequences, addition of a 3’ CCA tail, removal of introns, and formation of modified nucleosides. LÄS MER