Sökning: "metabolic inhibition"

Visar resultat 36 - 40 av 209 avhandlingar innehållade orden metabolic inhibition.

  1. 36. Vascular metabolomics : role of VEGF-B in fatty acid uptake and metabolic disease

    Författare :Carolina Hagberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The incidence of type 2 diabetes and the metabolic syndrome is rapidly increasing among both adults and children worldwide. Type 2 diabetes is strongly associated with obesity and ectopic lipid accumulation. Recent research has shown that peripheral insulin sensitivity is directly impaired by excessive lipid deposition within tissues. LÄS MER

  3. 37. Characterization of Impaired Glucose Tolerance - Insulin Sensitivity, Islet Function and Metabolic Risk Factors

    Författare :Hillevi Larsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; muscle fiber type; androgen activity; proinsulin; glucagon; insulin secretion; insulin sensitivity; Impaired glucose tolerance; type 2 diabetes; sekretion; diabetologi; Endokrinologi; diabetology; secreting systems;

    Sammanfattning : This thesis presents a three-year prospective study on metabolic characteristics of impaired glucose tolerance (IGT) and the regulation of insulin sensitivity versus islet function in relation to changes in glucose tolerance. 108 non-diabetic women aged 57-58 years were randomly selected from a population of women born in 1935 with a high prevalence of IGT. LÄS MER

  4. 38. The role of incretin peptides and ghrelin in upper gut motility and metabolic control

    Författare :Therese Edholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric emptying rate by gastrointestinal (GI) hormones. LÄS MER

  5. 39. Functional and metabolic alterations in skeletal muscle in response to physiological and pathophysiological stressors

    Författare :Theresa Mader; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle performance is essential for our body’s movement as well as for the wholebody metabolism. In health and disease, skeletal muscle is exposed to various endogenous and exogenous stressors, influencing its physiological functions. LÄS MER

  7. 40. Adverse drug effects on glucose and lipid metabolism: is human adipose tissue of importance?

    Författare :Assel Sarsenbayeva; Jan Eriksson; Mikael Rydén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human adipose tissue; metabolic adverse effects; SGAs; statins; glucocorticoids; glucose uptake; lipolysis; myofibroblasts; fibrosis; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Many pharmacological agents that are widely prescribed in clinical practice have adverse metabolic effects, such as hyperglycaemia, insulin resistance, and diabetes. Among such drugs are antipsychotics, prescribed for treatment of schizophrenia; statins, which inhibit cholesterol synthesis and prevent cardiovascular events; finally, potent anti-inflammatory agents, glucocorticoids. LÄS MER