Sökning: "metabolic inhibition"

Visar resultat 21 - 25 av 209 avhandlingar innehållade orden metabolic inhibition.

  1. 21. Heart failure : role of metabolic biomarkers, ejection fraction, and sex

    Författare :Ulrika Ljung Faxén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range EF(HFmrEF), and reduced EF(HFrEF). LÄS MER

  3. 22. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  4. 23. Genetic and metabolic studies of APOE, PCSK9, TM6SF2 and PNPLA3

    Författare :Hovsep Mahdessian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipids – including fatty acids (FAs), triglycerides (TGs), cholesterol and cholesterol esters (CEs) – are hydrophobic molecules involved in several important structural and mechanistic processes. Lipids are found in cellular membranes, give posture and stability to the cell, are actively participating in cellular signaling, and act as mediators in several important biological pathways. LÄS MER

  5. 24. Regulation of experimentally induced airway obstruction

    Författare :Eva G. Lindström; Jan Lötvall; Linköpings universitet; []
    Nyckelord :airway obstruction; antigen; capsaicin; epithelium; inflammatory mediators; sensory neurons; tube preparation; tachykinins; formoterol; histamine; presynaptic inhibition; in vitro; guinea pig; MEDICINE; MEDICIN;

    Sammanfattning : Asthma is one of the commonest diseases in industrialized countries. The cause and mechanisms of !he disorder are still not fully unden;tood, al!hough it is known that inflammation in !he airways plays an important role. Inflammatory mediators, e.g. LÄS MER

  7. 25. Engineered Yeast as Biocatalyst for Stereoselective reductions of Dicarbonyl Compounds

    Författare :Ted Johanson; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; chiral; screening; process optimisation; metabolic engineering; dicarbonyl; biocatalysis; yeast; bioreduction; Biotechnology; Bioteknik;

    Sammanfattning : Chiral building blocks are needed in the chemical and pharmaceutical industries for the production of fine chemicals and pharmaceuticals. The utilisation of microorganisms and enzymes to perform stereoselective reductions of carbonyl compounds is an efficient and widely applied method for the generation of chiral molecules. LÄS MER