Sökning: "androgen activity"

Visar resultat 1 - 5 av 54 avhandlingar innehållade orden androgen activity.

  1. 1. Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Hannah Nenonen; Lunds universitet.; Lund University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgen receptor; polymorphism; CAG polymorphism; androgen receptor activity; infertility; prostate cancer; androgen receptor function;

    Sammanfattning : The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. LÄS MER

  2. 2. Seasonal variations in general activity, behaviour and cutaneous glandular structures in reindeer (Rangifer tarandus L.)

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Torgny Mossing; Umeå universitet.; [1980]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Androgen; Cervidae; dermal glands; locomotor activity olfactory communicatiorL pheromones; photoperiod; rein deer; rut; seasonal variations;

    Sammanfattning : The locomotor activity of the reindeer is separated into a diurnal and a nocturnal phase which, in turn, consists of a  number of short-term activity bursts. The onset and termination  of diurnal and nocturnal activity are largely in synchrony  with sunrise and sunset. LÄS MER

  3. 3. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Detta är en avhandling från Umeå : Umeå University

    Författare :Emma Jernberg; Umeå universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  4. 4. Genetic, environmental and life-style effects on androgen receptor function

    Detta är en avhandling från Lund University

    Författare :Christel Björk; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

    Sammanfattning : Popular Abstract in Swedish De senaste årtiondena har det diskuteras om det finns anledning till oro när det gäller mannens reproduktionsfunktion. Vissa forskningsresultat tyder på att spermieantalet har minskat och fler män har diagnostiserats med testikelcancer och medfödda missbildningar av könsorganen än tidigare. LÄS MER

  5. 5. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation Special Focus on Vitamin D and Sex Hormones

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Lundqvist; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. LÄS MER