Sökning: "insulin signalling"

Visar resultat 11 - 15 av 116 avhandlingar innehållade orden insulin signalling.

1. 11. Insulin promotes GABA signalling modulation in both the mouse hippocampus and human CD4+ T cells

   Författare :Hayma Hammoud; Bryndis Birnir; Fredrik Elinder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gamma-aminobutyric acid; hippocampus; tonic currents; CD4 T cells; glucose; insulin; cytokines; proliferation.; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in the adult mammalian brain, where it mediates several biological functions. Rapid inhibition is predominantly mediated by the activation of GABA-A receptors that are ubiquitously expressed across the central nervous system in a cell-, circuit-, or region-specific manner. LÄS MER

3. 12. Adipocyte phosphatases and the antilipolytic action of insulin

   Författare :Svante Resjö; Signaltransduktionsforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein phosphorylation; protein purification; adipose tissue; PP2A; protein phosphatase; PDE3B; phosphodiesterase 3B; Insulin signalling; antilipolysis; Klinisk biologi; Clinical biology; PKB; protein kinase B;

   Sammanfattning : Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. LÄS MER

4. 13. α-Cell signalling in glucose-regulated glucagon secretion

   Författare :Qian Yu; Anders Tengholm; Erik Gylfe; Sebastian Barg; David W Piston; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islets; glucagon; insulin; somatostatin; ATP; cAMP; Ca2 ; GHB; oscillations; α-cell; β-cell; δ-cell; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Glucagon is a blood glucose-elevating hormone released from α-cells in the islets of Langerhans during hypoglycaemia. Glucagon is critical for glucose homeostasis and inappropriate regulation of its secretion underlies both impaired counter-regulation of hypoglycaemia and chronic hyperglycaemia in diabetes patients. LÄS MER

5. 14. Salt-inducible kinases in adipose tissue

   Författare :Johanna Sernevi Säll; Proteinfosforylering; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; salt-inducible kinase; SIK; SIK2; fettväv; fettceller; insulinsignalering; glukosupptag; fetma; insulinresistens; salt-inducible kinase; SIK; SIK2; adipose tissue; adipocytes; insulin signalling; glucose uptake; obesity; insulin resistance;

   Sammanfattning : Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. LÄS MER

7. 15. Lipid Metabolism and Insulin Signalling in Adipocytes : enhanced autophagy in type 2 diabetes

   Författare :Anita Öst; Peter Strålfors; Johanna Gustavsson Dahlberg; Anna Krook; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Energy storage in the adipose tissue, to an extent leading to obesity, is associated with local as well assystemic insulin resistance. When insulin-producing beta-cells in the pancreas gradually fail tocompensate, plasma levels of glucose rise and overt type 2 diabetes is diagnosed. LÄS MER