Sökning: "Peter Strålfors"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Peter Strålfors.

  1. 1. Insulin Signaling in Human Adipocytes a Systems Biology Approach

    Författare :Cecilia Brännmark; Peter Strålfors; Gunnar Cedersund; Peter Arner; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Obesity and a sedentary life style are associated with type 2 diabetes, a disease starting with insulin resistance in the adipose tissue, which spreads to the whole body. Despite large research efforts to understand the insulin signaling system, there is little knowledge of the mechanisms behind insulin resistance and type 2 diabetes developments. LÄS MER

  3. 2. A molecular approach to insulin signalling and caveolae in primary adipocytes

    Författare :Karin Stenkula; Fredrik Nyström; Peter Strålfors; Peter Arner; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; caveolae; insulin signalling; adipocytes; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : The prevalence of type II diabetes is increasing at an alarming rate due to the western world lifestyle. Type II diabetes is characterized by an insulin resistance distinguished by impaired glucose uptake in adipose and muscle tissues. LÄS MER

  4. 3. Expanding role of caveolae in control of adipocyte metabolism : proteomics of caveolae

    Författare :Nabila Aboulaich; Peter Strålfors; Alexander Vener; Hans Jörnvall; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Insulin signalling; Fatty acid metabolism; Proteomics; Mass spectrometry; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The primary function of adipose tissue is to store energy in the form of triacylglycerol, which is hydrolyzed to fatty acids to supply other tissues with energy. While insulin promotes the storage of triacylglycerol, catecholamines stimulate its hydrolysis. LÄS MER

  5. 4. Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states

    Författare :Siri Aili Fagerholm; Peter Strålfors; Mats Söderström; Ulf Smith; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Increasing numbers of people world-wide develops the disease type 2 diabetes. Development of type 2 diabetes is characterized by a shift from an insulin sensitive state to an insulin resistant state in peripheral insulin responding organs, which originates from the development of insulin resistance in the adipose tissue. LÄS MER

  7. 5. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes

    Författare :Anna Danielsson; Peter Strålfors; Fredrik Nyström; Lena Stensson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; type 2 diabetes; insulin; insulin resistance; insulin signalling; phosphorylation; insulin receptor substrate 1; feedback control; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. LÄS MER