Sökning: "tonic currents"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden tonic currents.

  1. 1. Insulin promotes GABA signalling modulation in both the mouse hippocampus and human CD4+ T cells

    Författare :Hayma Hammoud; Bryndis Birnir; Fredrik Elinder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gamma-aminobutyric acid; hippocampus; tonic currents; CD4 T cells; glucose; insulin; cytokines; proliferation.; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in the adult mammalian brain, where it mediates several biological functions. Rapid inhibition is predominantly mediated by the activation of GABA-A receptors that are ubiquitously expressed across the central nervous system in a cell-, circuit-, or region-specific manner. LÄS MER

  3. 2. GABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator

    Författare :Omar M. Babateen; Bryndis Birnir; Lena Eliasson; Uppsala universitet; []
    Nyckelord :Neuroscience; Neurovetenskap;

    Sammanfattning : GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains.  It binds to GABA-A and GABA-B receptors. The GABA-A receptors are ligand-gated chloride channels. A variety of GABA-A receptor agonists and antagonists have been developed to study the GABA-mediated inhibition and to explore new medications. LÄS MER

  4. 3. Physiology and Pharmacology of GABAA receptors: The Brakes in the Brain

    Författare :Catarina Lindquist; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; Ion channels; GABA; Inhibition;

    Sammanfattning : Inhibitory neurotransmission in the brain is mostly mediated by gamma-aminobutyric acid type A (GABAA) receptors. These receptors are involved in both phasic inhibition (point-to-point inhibition, synaptic transmission) and tonic inhibition (diffuse form of inhibition, brain homeostasis). LÄS MER

  5. 4. Anatomical studies of hypothalamic thyrotropin-releasing hormone : implications for motivated states

    Författare :Emilia Horjales-Araújo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The survival of every animal as an organism and species depends on three motivated states: ingestive, defensive and reproductive. Regulation of these states is coordinated by the hypothalamus through the coordination of three principal output pathways: behavioural, endocrine and autonomic. LÄS MER

  7. 5. The Cross-Talk between GABA Signalling and Metabolic Hormones in the Brain and Pancreatic Islets

    Författare :Yang Jin; Bryndis Birnir; Vidar Gundersen; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : GABA is a well-known neurotransmitter that can be synthesized in the central nervous system (CNS) and, interestingly, also in pancreatic islets. Once released, GABA activates GABA-A channels tonically or transiently resulting in different physiological functions. LÄS MER