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Visar resultat 1 - 5 av 112 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Biomarkers of inflammation in atrial fibrillation

   Författare :Julia Aulin; Jonas Oldgren; Ziad Hijazi; Lars Wallentin; Håkan Wallén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrial fibrillation; biomarkers; inflammation; inflammatory biomarkers; oral anticoagulation; heart failure; left ventricular function; ejection fraction; risk assessment; risk prediction; interleukin 6 IL-6 ; C-reactive protein CRP ;

   Sammanfattning : Atrial fibrillation (AF) is common and associated with increased risk of stroke, heart failure (HF) and mortality. Inflammation is linked to AF.The overall aim of this thesis was to investigate inflammatory activity and cardiovascular outcomes and mortality in patients with AF on effective oral anticoagulation. LÄS MER

3. 2. Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids

   Författare :Anne-Li Lind; Torsten Gordh; Masood Kamali-Moghaddam; Jonas Bergquist; Eva Kosek; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chronic pain; neuropathic pain; lumbar radicular pain; amyotrophic lateral sclerosis; radiculopathy; fibromyalgia; pathophysiology; spinal cord stimulation; mechanism of action; disc herniation; cerebrospinal fluid; plasma; biomarker; human; protein; chemokines; cytokines; inflammation; neuroinflammation; mass spectrometry; proximity ligation assay; proximity extension assay; antibody suspension bead array; protein profiling; molecular medicine; personalized medicine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Chronic pain affects 20 % of the global population, causes suffering, is difficult to treat, and constitutes a large economic burden for society. So far, the characterization of molecular mechanisms of chronic pain-like behaviors in animal models has not translated into effective treatments. LÄS MER

4. 3. Exploring Links between Melatonin, Inflammation and Depression

   Författare :Isak Sundberg; Janet Cunningham; Lisa Ekselius; Daniel Lindqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; melatonin; inflammation; depression; biomarkers; cytokines; anxiety; hepatitis C; Psychiatry; Psykiatri;

   Sammanfattning : Major depressive disorder (MDD) is one of the leading global causes of disease burden. Worse yet, about one third of the patients with MDD do not experience a remission with current treatments. LÄS MER

5. 4. Circulating biomarkers in patients with abdominal aortic aneurysm

   Författare :Despina Flondell-Sité; Vaskulära sjukdomar - kliniska studier; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; matrix metalloproteinases; biomarkers; risk factors; fibrinolysis; coagulation; inflammation; Abdominal aortic aneurysm; statin; interleukin 6.; APC-PCI complex; serpine-1; endothelin-1;

   Sammanfattning : Abdominal aortic aneurysm (AAA) develops in 3-6% of the population over 65 years and affects mainly men. AAA has a complex etiology involving inflammation, proteolysis, fibrinolysis and coagulation. LÄS MER

7. 5. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

   Författare :Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

   Sammanfattning : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. LÄS MER