Sökning: "Procollagen"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet Procollagen.

  1. 1. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

    Författare :Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

    Sammanfattning : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. LÄS MER

  3. 2. Osteogenesis Imperfecta : Genetic and Therapeutic Studies

    Författare :Katarina Lindahl; Östen Ljunggren; Andreas Kindmark; Carl-Johan Rubin; David Sillence; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OI; BMD; Genotype; Phenotype; Pharmaco-genetics; Bisphosphonate; Therapy; Gene-therapy; Mutation; Collagen; Collagen type I; Allele-specific silencing; siRNA; RNAi; COL1A1; COL1A2; Stroke; C-propeptide; Mineralization; Heterozygous disadvantage; Genetics; Genetik; Medicin; Medicine; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Osteogenesis imperfecta (OI) is a heterogeneous disease of connective tissue, the cardinal symptom being fractures and severity ranging from mild to lethal. Dominant mutations in collagen I, encoded by COL1A1 and COL1A2, cause >90% of cases. LÄS MER

  4. 3. Female stress incontinence and uterovaginal prolapse : collagen turnover and hormone sensitivity in urogenital tissue

    Författare :Lena Edwall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stress incontinence; urogenital tissue; collagen turnover markers; estradiol- 17beta; estrone; testosterone; uterovaginal prolapse; menopause;

    Sammanfattning : Background: Prevalence of both stress urinary incontinence (SUI) and uterovaginal prolapse (UP) is high and rising with age. Risk factors include multiparity, obesity, chronic obstructive lung disease and previous gynecological surgery. The underlying pathology is still unknown but may include defective connective tissue. LÄS MER

  5. 4. Biological aspects of synovial fluid mediated aseptic prosthesis loosening

    Författare :Martin Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aseptic loosening; synovial fluid; osteoblasts; bone resorption; IGF;

    Sammanfattning : Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. LÄS MER

  7. 5. Production of neocartilage tissues using primary chondrocytes

    Författare :Janne Ylärinne; Mikko Lammi; Chengjuan Qu; Mats Brittberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary chondrocytes; articular cartilage; tissue engineering; neocartilage; scaffold; scaffold-free; hyaluronan; self-assembling peptide; TGF-β3; glucosamine sulfate; hypoxia; hypertonic medium; glucose;

    Sammanfattning : Hyaline cartilage is a highly specialized tissue, which plays an important role in the articulating joints of an individual. It provides the joints with a nearly frictionless, impact resisting surface to protect the ends of the articulating bones. LÄS MER