Sökning: "glycine receptor"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden glycine receptor.

  1. 1. Role of glycine receptors in the regulation of dopamine activity and ethanol intake in the rat

    Författare :Anna C Molander; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Strychnine-sensitive glycine receptor GlyR ; dopamine; ethanol; nucleus accumbens nAc ; glycine; taurine; glycine re-uptake inhibitor GLYT1 ;

    Sammanfattning : .... LÄS MER

  2. 2. Galanin receptor ligands : Design, synthesis, characterization and biological effects

    Författare :Kristin Webling; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Galanin is a 29/30 amino acid long bioactive peptide discovered over 30 years ago when C-terminally amidated peptides were isolated from porcine intestines. The name galanin originates from a combination of the first and last amino acids - G from glycine and the rest from alanine. LÄS MER

  3. 3. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

    Författare :Christian Sköld; Anders Karlén; Anders Hallberg; Torbjörn Lundstedt; Tommy Liljefors; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; Angiotensin II; AT1; AT2; SAR; bioactive conformation; turn mimetic; peptidomimetic; DISCO; homology model; 3D-QSAR; CoMFA; Farmaceutisk kemi;

    Sammanfattning : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). LÄS MER

  4. 4. GABA-, glycine- and glutamate-induced currents in rat medial preoptic neurons : functional interactions and modulation by capsaicin

    Författare :Urban Karlsson; Staffan Johansson; Johannes Krupp; Bryndis Birnir; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic transmission; glutamate; GABA; glycine; TRPV1; Physiology; Fysiologi;

    Sammanfattning : The medial preoptic nucleus (MPN) of the hypothalamus plays a major role in many functions involved in maintaining bodily homeostasis, such as thermoregulation and osmoregulation, as well as in the control of complex behaviours, e.g. sexual behaviour. LÄS MER

  5. 5. Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol

    Författare :Susanne Jonsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :glycine receptor; nucleus accumbens; alcohol; gene expression; dopamine;

    Sammanfattning : The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty concerning how alcohol exerts its effects and the mechanisms behind the transition from consumption to addiction. LÄS MER