Sökning: "nucleus accumbens nAc"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden nucleus accumbens nAc.
1. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat
Sammanfattning : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. LÄS MER
2. Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms
Sammanfattning : The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine receptors (nAChRs) within this system appear important for the pharmacological actions of both alcohol and nicotine, which may explain the frequent co-abuse of these two drugs. LÄS MER
3. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
Sammanfattning : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. LÄS MER
4. Taurine and dopamine-related effects of ethanol. An experimental study in rodents
Sammanfattning : The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought to be a predominant underlying factor in promoting excessive alcohol intake and alcohol use disorder. LÄS MER
5. Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol
Sammanfattning : The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty concerning how alcohol exerts its effects and the mechanisms behind the transition from consumption to addiction. LÄS MER