Sökning: "glycine receptor"

Visar resultat 16 - 20 av 37 avhandlingar innehållade orden glycine receptor.

1. 16. ß-Adrenergic receptor gene polymorphism in dilated cardiomyopathy. Clinical and functional relevance

   Författare :Malin Levin; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : During normal physiological conditions, catecholamines induce positive inotropic and chronotropic responses in the heart through a ß-adrenergic receptor (AR)-activated pathway. The agonist-bound ßAR selectively interacts with the stimulatory Gs-protein, which activates adenylyl cyclase, catalyzing cAMP formation. LÄS MER

3. 17. Characterization of peroxisome proliferator-activated receptor alpha (PPARa) regulated acyl-CoA thioesterases involved in lipid metabolism

   Författare :Mary C Hunt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; coenzyme A; bile acid metabolism; lipid metabolism.;

   Sammanfattning : The peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor in the control of lipid metabolism. Target genes for PPARalpha include many enzymes involved in the oxidation of fatty acids in mitochondria and peroxisomes. LÄS MER

4. 18. Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents

   Författare :Jakob Michaëlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NK cells; MHC class 1; inhibitory receptors;

   Sammanfattning : Natural Killer (NK) cells are an important part of the innate immune system. They can lyse target cells and secrete immunoregulatory cytokines early during immune responses. They mediate protection against viruses and tumours, and can reject MHC class I mismatched bone marrow grafts. LÄS MER

5. 19. Regulation of protein degradation by virus derived repeated amino acid sequences

   Författare :Ainars Leonchiks; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Epstein-Barr virus; glycine-alanine repeat; ubiquitin-proteasome pathway;

   Sammanfattning : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. LÄS MER

7. 20. On amino acid neurotransmitters in the spinal cord motor nuclei

   Författare :Göran Örnung; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurotransmitter; aspartate; glutamate; GABA. glycine; homocysteate; taurine; ultrastructure; freeze-substitution; immunocytochemistry; bouton; synaptic input; motoneuron; strech reflex; spinal cord; cat. rat;

   Sammanfattning : Using pre- and post-embedding immunocytochemistry, the distribution of six amino acid neurotransmitter candidates, with special reference to y-amino-butyric acid (GABA), glycine and glutamate was examined in boutons apposing somata and dendrites in the lumbar motor nuclei of the cat spinal cord. The monosynaptic connection between muscle spindle I a afferents and motoneurons regarding content of neuroactive amino acid and complement of amino acid receptors in the postsynaptic membrane was studied in the rat. LÄS MER