Sökning: "genetically modified mice"

Visar resultat 1 - 5 av 58 avhandlingar innehållade orden genetically modified mice.

1. 1. Vascular Wall Responses to Bypass Grafting - Studies in Mice

   Författare :Klas Österberg; Göteborgs universitet; []
   Nyckelord :Intimal hyperplasia; graft stenosis; smooth muscle cells; mice; cellular recruitment;

   Sammanfattning : Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia (IH). It is assumed that exaggerated intimal thickening is initiated by vessel wall injuries or local flow disturbances. LÄS MER

3. 2. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

   Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER

4. 3. Physiological roles of A1 and A2A adenosine receptors : studies using genetically modified mice

   Författare :Jiang-Ning Yang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine receptors; genetically modified mice; preconditioning; tolerance; heart rate; body temperature; locomotor activity; caffeine;

   Sammanfattning : Since adenosine receptors were identified and cloned, their roles in animals and humans have been extensively studied. Because pharmacological tools have limitations, we have used mice in which adenosine receptors have been deleted to further study their roles under physiological and pathophysiological conditions. LÄS MER

5. 4. Metabolic roles of adenosine : studies using genetically modified mice and transfected cells

   Författare :Stina Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; A1 receptor; adipocyte; pancreas; skeletal muscle; GHSR1a; caffeine; metabolism and knock out mouse;

   Sammanfattning : The aim of this thesis was to further investigate the metabolic roles of adenosine. The endogenous nucleoside adenosine acts by binding to the four adenosine receptors, A1R, A2AR, A2BR and A3R. The A1R is the adenosine receptor that has been proposed to be the one most involved in metabolism. LÄS MER

7. 5. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

   Författare :Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. LÄS MER