Sökning: "fk506"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet fk506.

  1. 1. Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro

    Författare :Håkan Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokine; adhesion molecule; endothelium; lymphocyte metabolism; interleukin 2 receptor; FK506; cyclosporin A; Mikrobiologi; bakteriologi; virologi; mykologi; Immunology; transplantation; serology; Microbiology; bacteriology; mycology; virology; Immunologi; serologi;

    Sammanfattning : In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. LÄS MER

  3. 2. Molecular dynamics studied by NMR relaxation experiments. Characterization of functional dynamics in the FK506 binding protein FKBP12

    Författare :Ulrika Brath; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nuclear magnetic resonance; NMR; FK506; protein dynamics; chemical exchange; spin relaxation; FKBP12; FKBP; isotope labeling;

    Sammanfattning : The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. LÄS MER

  4. 3. Peripheral nerve reconstruction. Studies on cellular and acellular iso-, allo- and xenografts

    Författare :Martin Kvist; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acellular nerve graft; costimulation blockade; FK506; immunosuppression; nerve graft; nerve defect; nerve regeneration; nerve injury; nerve extraction; allograft; xenograft;

    Sammanfattning : The best results after a nerve injury with a defect are achieved by a nerve reconstruction procedure using autologous nerve grafts. However, limitations include insufficient amount of suitable donor material and donor site morbidity. The aim of the present thesis was to study alternative nerve grafts, i.e. LÄS MER

  5. 4. Intestinal transplantation. Experimental and clinical studies

    Författare :Mihai Oltean; Göteborgs universitet; []
    Nyckelord :Intestinal preservation; Ischemia-reperfusion injury; Tight junction; FK506; Resistin;

    Sammanfattning : Intestinal preservation-reperfusion injury may result in various degrees of mucosal injury. Interestingly, the preservation injury is similar when using the current preservation solutions, which are given as a intravascular flush. An extensive mucosal injury may ultimately preclude the use of organs that require longer preservation time. LÄS MER

  7. 5. Effects and mechanisms of actions of cyclosporin, FK506 and 15-deoxyspergualin

    Författare :Anette Johansson Borg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cyclosporin; FK506; 15-deoxyspergualin; immunosuppressive effects; transplantation;

    Sammanfattning : Immunosuppressive drugs can be used to deal with unwanted or inappropriate immune reactions, such as the rejection of a transplanted organ. However, treatment with these drugs are often associated with serious adverse effects, and therefore less toxic immunosuppressants are desired. LÄS MER