Sökning: "amyloid-β peptide"
Visar resultat 1 - 5 av 71 avhandlingar innehållade orden amyloid-β peptide.
1. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease
Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER
2. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization
Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER
3. On the molecular mechanisms of the amyloid β-peptide aggregation
Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER
4. NMR studies on interactions between the amyloid β peptide and selected molecules
Sammanfattning : Alzheimer’s disease is an incurable neurodegenerative disorder linked to the amyloid β (Aβ) peptide, a 38-43 residue peptide. The detailed molecular disease mechanism(s) is (are) unknown, but oligomeric Aβ structures are proposed to be involved. LÄS MER
5. Modulation of amyloid β peptide self-assembly : Aggregation mechanisms associated with Alzheimer's disease
Sammanfattning : .... LÄS MER
