Sökning: "Ludmilla Morozova-Roche"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Ludmilla Morozova-Roche.

  1. 1. Protein complexes : assembly, structure and function

    Författare :Kristina Wilhelm; Ludmilla Ludmilla Morozova-Roche; Catharina Svanborg; Umeå universitet; []
    Nyckelord :HAMLET; ELOA; lysozyme; amyloid; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. LÄS MER

  3. 2. Amyloids here, amyloids there…What’s wrong with them?

    Författare :Anna Gharibyan; Ludmilla Morozova-Roche; Tuomas Knowels; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloids; oligomers; fibrils; cytotoxicity; Alzheimer s disease; Aortic stenosis; S100A9; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Amyloid formation is inherent property of proteins which under certain circumstances can become a pathologic feature of a group of diseases called amyloidosis. There are about 30 known human amyloidosis and more than 27 identified proteins involved in these pathologies. LÄS MER

  4. 3. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance

    Författare :Md Tohidul Islam; Anders Olofsson; Ludmilla Morozova-Roche; Vytautas Smirnovas; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; medicinal chemistry; läkemedelskemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. LÄS MER

  5. 4. The amyloid : structure, properties and application

    Författare :Mantas Malisauskas; Ludmilla Morozova-Roche; Fabrizio Chiti; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; oligomers; AFM; cytotoxicity; biotemplating; lysozyme; Biochemistry; Biokemi;

    Sammanfattning : Protein aggregation, leading to the formation and depositions of amyloids, is a cause for a number of diseases such as Alzheimer’s and Creutzfeld-Jacob’s disease, systemic amyloidoses, type II diabetes and others . More than 20 proteins are associated with protein misfolding diseases and even a larger number of proteins can self-assemble into amyloid in vitro. LÄS MER

  7. 5. Role of pro-inflammatory S100A9 protein in amyloid-neuroinflammatory cascade in Alzheimer’s disease and traumatic brain injury

    Författare :Chao Wang; Ludmilla Morozova-Roche; Jonathan Gilthorpe; Øyvind Halskau; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S100A9; Aβ; Alzheimer s disease; Traumatic brain injury; Amyloid; Neuroinflammatory; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Background Traumatic brain injury (TBI) is a complex disease with a spectrum of symptoms and disabilities. Over the past decade TBI has become the focus of research due to growing epidemiological and clinical evidences that TBI incidences are strong risk factors for Alzheimer’s disease (AD). LÄS MER