Sökning: "15O-water PET"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden 15O-water PET.

  1. 1. Quantitative cardiac 15O-water PET : Assessment of left-ventricular function, remodeling, and impact of patient motion

    Författare :Jonny Nordström; Mark Lubberink; Jens Sörensen; Hendrik J Harms; Stephan Nekolla; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; positron emission tomography PET ; 15O-water; myocardial blood flow; cardiac remodeling; patient motion;

    Sammanfattning : International guidelines advocate the use of noninvasive cardiac imaging as the initial diagnostic test for coronary artery disease, the global leading cause of death according to the world health organization. Within the wide spectrum of cardiac imaging, 15O-water PET is the gold standard for noninvasive quantification of myocardial blood flow (MBF). LÄS MER

  3. 2. Methodological aspects of quantitative cardiac molecular imaging

    Författare :Tanja Kero; Mark Lubberink; Håkan Ahlström; Elin Trägårdh; Uppsala universitet; []
    Nyckelord :PET; cardiac amyloidosis; 11C-PIB; retention index; standardized uptake value; PET-MR; MRI; myocardial blood flow; 15O-water; quantification; quantitative modeling;

    Sammanfattning : The objective of this research was to facilitate the use of quantitative cardiac molecular imaging by developing and validating methods and applications. More specifically:we determined the optimal tracer kinetic model for analysis of 11C-PIB and evaluated the performance of two simpler measures, retention index (RI) and standardized uptake value (SUV), in the quantification of cardiac 11C-PIB uptake in amyloidosis. LÄS MER

  4. 3. On potentials and limitations of perfusion MRI in neurological disorders

    Författare :Markus Fahlström; Mark Lubberink; Adam Espe Hansen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurological disease; MRI; Perfusion; 15O-water PET; Medicinsk radiofysik; Medical Radiophysics;

    Sammanfattning : Cerebral perfusion outlines several parameters which describe the status of cerebral haemodynamics. Numerous neurological diseases affect cerebral perfusion, thus the importance of diagnostic measurements. LÄS MER

  5. 4. Positron Emission Tomography (PET) Studies in Anxiety Disorders

    Författare :Åsa Michelgård Palmquist; Mats Fredrikson; Lars von Knorring; Hans Ågren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; amygdala; fear; anxiety; anxiety disorders; specific phobia; social phobia; posttraumatic stress disorder; PTSD; regional cerebral blood flow; rCBF; substance P; SP; neurokinin 1 receptor; NK1; GR205171; STAI-S; Psychiatry; Psykiatri; Neurobiology; Neurobiologi; Neuroscience; Neurovetenskap; Experimental brain research; Experimentell hjärnforskning; Molecular neurobiology; Molekylär neurobiologi; Radiation biology; Strålningsbiologi; Neurobiology; Neurobiologi; Neurobiology; Neurobiologi;

    Sammanfattning : Anxiety disorders are very common and the primary feature is abnormal or inappropriate anxiety. Fear and anxiety is often mediated by the amygdala, a brain structure rich in substance P (SP) and neurokinin 1 (NK1) receptors. LÄS MER

  7. 5. PET in Heart Failure - Methods and Applications

    Författare :Jens Sörensen; Göran Hedenstierna; Elisabeth Ståhle; Bengt Långström; Juhani Knuuti; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; congestive heart failure; myocardial ischemia; positron emission tomography; left ventricular dysfunction; tracer kinetic models; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Positron Emission Tomography (PET) permits regional myocardial perfusion, fibrosis and oxidative metabolism to be non-invasively quantified with radioactive tracers such as [15O]-water and [1-11C]-acetate. PET is an established research tool in congestive heart failure (CHF), a major cause of morbidity and mortality. LÄS MER