Sökning: "enhancer conservation"

Hittade 4 avhandlingar innehållade orden enhancer conservation.

  1. 1. The role of Nkx3.2 and Gdf5 during zebrafish skeletal development

    Författare :Laura Waldmann; Tatjana Haitina; Abigail Tucker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nkx3.2; Gdf5; zebrafish; jaw joint; joints; axial skeleton; appendicular skeleton; fin; enhancer conservation; CRISPR Cas9; OPT;

    Sammanfattning : The vertebrate skeleton is composed of bony and cartilaginous structures that are developed under the control of numerous genetic networks. The transcription factor Nkx3. LÄS MER

  3. 2. Functional Characterization of the Evolutionarily Conserved Adenoviral Proteins L4-22K and L4-33K

    Författare :Sara Östberg; Göran Akusjärvi; Stefan Schwartz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; L4-33K; RNA; splicing; adenovirus; nuclear localization; replication; transcription; evolution; SR protein; MLP; promoter; E1A; serotypes;

    Sammanfattning : Regulation of adenoviral gene expression is a complex process directed by viral proteins controlling a multitude of different activities at distinct phases of the virus life cycle. This thesis discusses adenoviral regulation of transcription and splicing by two proteins expressed at the late phase: L4-22K and L4-33K. LÄS MER

  4. 3. Hunter-gatherer-annotator science : characterizing regulatory elements in the genome of dog and zebrafish with public and not yet public data

    Författare :Matthias Hörtenhuber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In order to study gene regulation, large amounts of sequencing data are necessary. We can either generate (hunt) them ourselves or use (gather) publicly available data sets. In order to guarantee the reliability and reusability of the hunted and gathered data, we need to also annotate them with the correct metadata. LÄS MER

  5. 4. Functional collaboration between HLH transcription factors in B cell development

    Författare :Ramiro Gisler; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Sammanfattning : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. LÄS MER