Sökning: "E1A"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet E1A.
1. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP
Sammanfattning : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. LÄS MER
2. Characterisation of CtBP : A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein
Sammanfattning : In this study, adenovirus E1A has been used to target and analyse the transcriptional function of the cellular C-terminal Binding Protein (CtBP).Transcription is a complex biochemical process that represents a major regulatory step in gene expression. LÄS MER
3. Functional Characterization of the Evolutionarily Conserved Adenoviral Proteins L4-22K and L4-33K
Sammanfattning : Regulation of adenoviral gene expression is a complex process directed by viral proteins controlling a multitude of different activities at distinct phases of the virus life cycle. This thesis discusses adenoviral regulation of transcription and splicing by two proteins expressed at the late phase: L4-22K and L4-33K. LÄS MER
4. The Modular Domain Structure of ASF/SF2: Significance for its Function as a Regulator of RNA Splicing
Sammanfattning : ASF/SF2 is an essential splicing factor, required for constitutive splicing, and functioning as a regulator of alternative splicing. ASF/SF2 is modular in structure and contains two amino-terminal RNA binding domains (RBD1 and RBD2), and a carboxy-terminal RS domain. LÄS MER
5. Splicing of adenovirus-2 E1A pre-messenger RNA : sequence requirement and the biological consequences of alternative RNA splicing
Sammanfattning : .... LÄS MER