Sökning: "HLH proteins"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden HLH proteins.
1. Functional collaboration between HLH transcription factors in B cell development
Sammanfattning : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. LÄS MER
2. Genetic, cellular and clinical studies of hemophagocytic lymphohistiocytosis
Sammanfattning : Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyperinflammatory condition characterized by fever, cytopenia, hepatosplenomegaly, and sometimes hemophagocytosis. HLH is typically divided into two distinct groups, primary HLH and secondary HLH. LÄS MER
3. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells
Sammanfattning : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. LÄS MER
4. Genetic predisposition to immune cell malfunction and inflammation
Sammanfattning : Our genome contains all the instructions to control the synthesis of proteins, the development of cells and the interaction between body systems. We are armed with an immune system, made up of cells, chemical compounds and physical barriers, that protects us from invading pathogens. LÄS MER
5. Transcriptional networks in neuroblastoma and breast cancer
Sammanfattning : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. LÄS MER