Sökning: "Early B cell Factor EBF"

Hittade 5 avhandlingar innehållade orden Early B cell Factor EBF.

  1. 1. Tissue specific functions of Early B-cell factor in cellular differentiation

    Författare :Anna Lagergren; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription factor; extracellular fluids; Haematology; tissue specific; cellular differentiation; EBF; Hematologi; extracellulära vätskor;

    Sammanfattning : This work focus on the functions by which the transcription factor Early B-cell Factor (EBF) regulate gene expression in different cell types. To address this question, gene expression analyses aimed to investigate the regulatory role of EBF in neuroblastoma cells, B-lymphocytes, adipocytes and stromal cells were performed. LÄS MER

  3. 2. Gene regulation by Early B-cell Factor (EBF)

    Författare :Peter Åkerblad; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; B-lymphocytes; Differentiation; Transcription; EBF; Gene regulation; transplantation; Immunologi; serologi;

    Sammanfattning : In this study we aimed at defining genes that are controlled by Early B-cell Factor (EBF), that could explain the severe block in B-cell development observed in EBF-/- mice. The fact that EBF appears to be important for the transcriptional control of genes encoding proteins in the pre-B and B-cell receptor complex implied to us that EBF could be a common regulator of other components in the pre-B and B-cell receptor. LÄS MER

  4. 3. Functional collaboration between HLH transcription factors in B cell development

    Författare :Ramiro Gisler; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Sammanfattning : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. LÄS MER

  5. 4. Genetic networks dictating early lymphoid lineage decision events

    Författare :Emma Smith; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; hematopoiesis; B-cell development; transcription; Notch; EBF; extracellulära vätskor;

    Sammanfattning : Differentiation from hematopoietic stem cells to mature blood cells of different lineages is a continuous process that requires the coordinated activity of several stage and lineage specific transcription factors. These factors act in a transcriptional hierarchy and also in a combinatorial manner to establish the expression of the genes that comprise a specific differentiation program. LÄS MER

  7. 5. Molecular cytogenetic characterization of chromosome aberrations in soft tissue and bone tumors

    Författare :Malin A Nilsson; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; breakpoint mapping; FISH; structural rearrangements;

    Sammanfattning : Bone and soft tissue tumors (BSTT) belong to a diverse group of solid tumors of mesenchymal origin, with a large number of histological types affecting individuals of all ages. The general aim of the present thesis (Articles I-V) was to investigate in detail the genetic aberrations in selected subtypes of benign and malignant BSTT. LÄS MER