Sökning: "E47"

Hittade 5 avhandlingar innehållade ordet E47.

  1. 1. Functional collaboration between HLH transcription factors in B cell development

    Författare :Ramiro Gisler; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Sammanfattning : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. LÄS MER

  3. 2. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

    Författare :Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER

  4. 3. A Study of the Surrogate Light chain

    Författare :Annica Mårtensson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; VpreB; lambda 5; transcription; B cell development; serologi;

    Sammanfattning : This thesis has investigated the importance of the VpreB1 protein in early B cell development. Mice lacking the VpreB1 protein showed normal numbers of peripheral mature B cells. LÄS MER

  5. 4. Regulation of B cell development by antigen receptors

    Författare :Jannek Hauser; Thomas Grundström; Yuan Zhuang; Umeå universitet; []
    Nyckelord :calcium; calmodulin; e-proteins; E2A; B cell development; antigen receptor signaling; surrogate light chains; RAG; allelic exclusion; V D J recombination; AID; negative feedback regulation; plasma cell differentiation;

    Sammanfattning : The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. LÄS MER

  7. 5. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells

    Författare :Paula Persson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; Id; Olf EBF; ubiquilin-1; HASH-1; bHLH; Neuroblastoma; neuronal differentiation; cancer; onkologi; cancerology; Cytologi;

    Sammanfattning : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. LÄS MER