Sökning: "endogenous factors"

Visar resultat 16 - 20 av 315 avhandlingar innehållade orden endogenous factors.

1. 16. On VEGF and related factors in neurotrauma

   Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

   Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER

3. 17. Natural killer cells : studies on genetic, endogenous and exogenous factors controlling the expression of natural killer cell activity

   Författare :Anders Örn; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

4. 18. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER

5. 19. Early Environment and Adolescent Ethanol Consumption : Effects on Endogenous Opioids and Behaviour in Rats

   Författare :Loudin Daoura; Ingrid Nylander; Erika Roman; Bo Söderpalm; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcohol; intermittent ethanol access; maternal separation; multivariate concentric square field™ test; maternal behavior; ultrasonic vocalization; adolescent; neonatal handling; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Sammanfattning : Excessive and compulsive ethanol drinking is one of the most serious public health issues. Therefore, it is vital to increase the knowledge about risks and protection for alcohol use disorders (AUD) to optimize prevention and treatment strategies. LÄS MER

7. 20. Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics

   Författare :Jenna Najar; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Alzheimer s disease; Epidemiology; Marital status; Leisure time activity; Menopause; Polygenic risk scores; APOE genotype;

   Sammanfattning : Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Method: We used population-based samples from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study). LÄS MER