Sökning: "APOE genotype"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden APOE genotype.

  1. 1. Biomarkers for Alzheimer's disease and the APOE polymorphism

    Författare :Ronald Lautner; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER

  3. 2. Cognitive change in aging: A life span perspective of gender and individual differences in APOE genotype

    Författare :Marcus Praetorius; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; cognitive performance; late life; APOE; gender; time to death;

    Sammanfattning : Degree of licentiate in Psychology Abstract Praetorius, M. (2011). Cognitive change in aging: A life span p erspective of gender and individual differences in APOE genotype. LÄS MER

  4. 3. Coffee and gene interaction. The effect on methionine and lipid metabolism

    Författare :Elisabeth Strandhagen; Göteborgs universitet; []
    Nyckelord :coffee; homocysteine; cholesterol; folate; pyridoxine; MTHFR; APOE; gene; polymorphism; interaction;

    Sammanfattning : Background: Different dietary factors influence the risk of coronary heart disease (CHD), most likely in an interaction with genetic polymorphisms. The knowledge about such interactions is insufficient. Some observational studies have shown an association between coffee and CHD, others have not. Coffee consumption affects some CHD risk factors, e. LÄS MER

  5. 4. Air pollution and dementia in a low exposure setting : the role of noise, olfaction, and theapoe gene

    Författare :John Andersson; Maria Nordin; Anna Oudin; Anna Sundström; Tom Russ; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Air pollution; Road traffic; NOx; dementia; APOE; Alzheimer’s disease; Apolipoprotein E; olfaction; particulate matter; vascular dementia; odor identification; odor detection; Psychology; psykologi;

    Sammanfattning : Previous research indicates an association between air pollution exposure, and risk of dementia. Still, a number of factors that may play a role in this association remain to be explored. LÄS MER

  7. 5. Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics

    Författare :Jenna Najar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Alzheimer s disease; Epidemiology; Marital status; Leisure time activity; Menopause; Polygenic risk scores; APOE genotype;

    Sammanfattning : Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Method: We used population-based samples from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study). LÄS MER