Sökning: "Polygenic risk scores"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Polygenic risk scores.
1. Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics
Sammanfattning : Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Method: We used population-based samples from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study). LÄS MER
2. Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models
Sammanfattning : Background: Taxane-induced peripheral neuropathy (TIPN) is a common and distressful side effect. Little is known on how long TIPN persist and its effect on health-related quality of life (HRQL). LÄS MER
3. Genetic Predisposition to Sporadic and Familial Multiple Myeloma
Sammanfattning : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. LÄS MER
4. Understanding the genetic architecture of fatty liver disease
Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. LÄS MER
5. Epidemiological studies on breast cancer risk factors and screening
Sammanfattning : This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors of women and cancer risk among their relatives. Specifically, four studies were conducted using data from Swedish national registers, the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) cohort, and the Linné-Bröst1 (Libro-1) cohort. LÄS MER