Sökning: "HIF1alpha"

Hittade 4 avhandlingar innehållade ordet HIF1alpha.

  1. 1. On VEGF and related factors in neurotrauma

    Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

    Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER

  3. 2. Hypoxia inducible factor 1alpha : molecular mechanisms of regulation

    Författare :William J Wilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to hypoxia, including induction of vascular endothelial growth factor (VEGF) gene expression. LÄS MER

  4. 3. Analysis of HIF-1alpha degradation and function

    Författare :Helder André; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

    Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER

  5. 4. The role of Notch signaling in cancer and metastasis

    Författare :Anders P Mutvei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide range of cellular contexts and dysregulated Notch signaling has been linked to a number of diseases, including cancer. LÄS MER