Sökning: "VEGFR2"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet VEGFR2.

  1. 1. Regulation of VEGFR2 signaling in angiogenesis and vascular permeability

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Chiara Testini; Lena Claesson-Welsh; Mats Hellström; Mauro Giacca; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGFR2; angiogenesis; permeability; NRP1; Y949; Y1212; paladin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Angiogenesis and vascular permeability occur in physiological and pathological conditions. Angiogenesis denotes the process of blood vessel formation from preexisting quiescent vessels. LÄS MER

  2. 2. Affibody Molecules Targeting VEGFR2 - Two Turns Off and Four Turns On

    Detta är en avhandling från KTH Royal Institute of Technology

    Författare :Rezan Güler; John Löfblom; Stefan Ståhl; Dario Neri; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; affibody molecules; VEGFR2; angiogenesis; Biotechnology; Bioteknologi;

    Sammanfattning : The notion of employing proteins as drugs traces back several decades. As recombinant DNA technology emerged, it became a powerful tool for the tailoring of protein traits via genetic approaches - so-called protein engineering. LÄS MER

  3. 3. Neuropilin-1 regulation of tumor vascularization and growth

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Eric Morin; Lena Claesson-Welsh; Hellmut Augustin; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Neuropilin-1; VEGFR2; tumor biology; pancreatic ductal adenocarcinoma; renal cell carcinoma; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. LÄS MER

  4. 4. Bacterial display systems for engineering of affinity proteins

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Filippa Fleetwood; John Löfblom; Harald Kolmar; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Combinatorial protein engineering; staphylococcal display; Affibody; biparatopic; VEGFR2; nanobody; E. coli display; autotransporter; Biotechnology; Bioteknologi;

    Sammanfattning : Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. LÄS MER

  5. 5. Exploring Cellular Dynamics From Vesicle Tethering to Cell Migration

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Parham Ashrafzadeh; Johan Kreuger; Jonas Fuxe; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; cancer; cell migration; exocyst complex; exocytosis; FGD5; lipid rafts; plasma membrane; receptor trafficking; VEGFR2;

    Sammanfattning : Cells in the body communicate with each other in order to cooperate efficiently. This communication is in part achieved by regulated secretion of signaling molecules, which when released from a cell may activate receptors present at the plasma membrane of an adjacent cell. Such signals affect both cell fate and behavior. LÄS MER