Sökning: "electrophiles"

Visar resultat 11 - 15 av 37 avhandlingar innehållade ordet electrophiles.

  1. 11. Exploring medical applications of a bioactive polymer

    Författare :Felix Sellberg; David Berglund; Buddy Ratner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bioactive polymer; oncology; immunology; radiology; ischemia; translational research;

    Sammanfattning : In this thesis, we have studied a polymeric compound called PVAC, designed as a scavenger of reactive electrophilic substances. We explored several diseases where these substances are overproduced.In Paper I, adhesion formation was induced via bowel anastomosis surgery in rats. LÄS MER

  3. 12. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Författare :Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Sammanfattning : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. LÄS MER

  4. 13. Synthesis of 18F- and 76Br-labelled oligonucleotide and nucleoside derivatives

    Författare :Elisabeth Hedberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : With the aim of developing synthetic routes to oligodeoxynucleotides and analogues labelled with the positron-emitting radionuclides 18F and 76Br (half-lives 1.8 and 16. LÄS MER

  5. 14. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

    Författare :Jerk Rönnols; Göran Widmalm; Mikael Bols; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Conformation; NMR spectroscopy; Hydrogen bond; organisk kemi; Organic Chemistry;

    Sammanfattning : The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings.The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. LÄS MER

  7. 15. Development and Applications of Molybdenum-Catalyzed Chemoselective Amide Reduction

    Författare :Tove Slagbrand; Hans Adolfsson; André Charette; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrosilylation; reduction; reductive functionalization; catalysis; amides; enamines; chemoselective; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis covers the development of catalytic methodologies for the mild and chemoselective hydrosilylation of amides. The first part describes the investigation of the Mo(CO)6-catalyzed reduction of carboxamides. LÄS MER